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ID 114089
Title Alternative
RVS for small lesion in hepatectomy
Author
Araki, Kenichiro Gunma University
Harimoto, Norifumi Gunma University
Muranushi, Ryo Gunma University
Hoshino, Kouki Gunma University
Hagiwara, Kei Gunma University
Yamanaka, Takahiro Gunma University
Ishii, Norihiro Gunma University
Tsukagoshi, Mariko Gunma University
Igarashi, Takamichi Gunma University
Watanabe, Akira Gunma University
Kubo, Norio Gunma University
Shirabe, Ken Gunma University
Keywords
real-time virtual sonography
small liver metastatic lesion
sonazoid enhancement
hepatectomy
chemotherapy
Content Type
Journal Article
Description
Background : Systemic chemotherapy can drastically downsize metastatic liver tumors and these small liver lesions could sometimes be difficult for surgeons to detect during hepatectomy. We assessed the usefulness of intraoperative real-time virtual sonography (RVS) with contrast-enhanced ultrasonography (CEUS) using ‘Sonazoid’ contrast agent (RVS-CEUS). Methods : We performed the intraoperative RVS-CEUS technique on 10 tumor lesions in six cases, which were scheduled for hepatic resection of < 10 mm in diameter in our liver metastases series. These lesions were preoperatively diagnosed by contrast enhanced-computed tomography (CE-CT) or Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (EOB-MRI). We assessed the detectability of a tumor with RVS-CEUS during surgery and compared it with that of preoperative CE-CT or EOB-MRI. Results : Detectability of RVS-CEUS for 10 small lesions was 90% (n = 9/10) and that of other preoperative modalities were 50% (n = 5/10, CE-CT) and 100% (n = 10/10, EOB-MRI). Minimum tumor size detected was 3.0 mm in diameter, and maximum depth of detection with RVS-CEUS was 43.5 mm ; these results could be an advantage when compared with other intraoperative diagnostic modalities. Conclusion : Intraoperative RVS-CEUS was useful for detecting small metastatic liver lesions after chemotherapy and could be an effective intraoperative diagnostic technique for hepatic resection of a size < 10 mm.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA12022913
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
66
Issue
3-4
Start Page
319
End Page
323
Sort Key
319
Published Date
2019-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher