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ID 114357
Title Alternative
REARRANGEMENT OF c-myc GENE
Author
Shiraishi, Masahiko National Cancer Center Research Institute
Hirohashi, Setsuo National Cancer Center Research Institute
Morinaga, Shojiroh National Cancer Center Research Institute
Shimosato, Yukio National Cancer Center Research Institute
Sugimura, Takashi National Cancer Center Research Institute
Sekiya, Takao National Cancer Center Research Institute
Keywords
c-myc
Rearrangement of gene
Giant cell carcinoma of the lung
Content Type
Journal Article
Description
The c-myc oncogene was found to be rearranged in a human cell line of giant cell carcinoma of the lung (C-Lu65) and in a human primary giant cell carcinoma of the lung (LuC38C). The rearrangements in C-Lu65 and LuC38C were in regions about 7.5kb and 6kb, respectively, upstream from the transcription initiation site. No rearrangement of the c-myc gene was observed in a non-cancerous portion (LuC38N) of the lung of the patient who carried LuC38C. These results suggest that rearrangement of the c-myc gene may play some role in tumorigenesis of giant cell carcinoma of the lung.
Journal Title
Japanese Journal of Cancer Research
ISSN
09105050
NCID
AA00690844
Publisher
Japanese Cancer Association
Volume
77
Issue
8
Start Page
731
End Page
735
Published Date
1986-08
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences