| ID | 25668 |
| Author |
Hagi, Akifumi
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
Hayashi, Hideki
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
Kishi, Kazuhiro
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
Lihong, Wang
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
Ebina, Yousuke
Division of Molecular Genetics, Institute for Enzyme Research, The University of Tokushima
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| Keywords | fMLP
PAF
glucose transport
GLUT1
G-protein coupled receptor
|
| Content Type |
Journal Article
|
| Description | The chemoattractants, fMLP and PAF, stimulate glucose uptake in phagocytes to obtain an energy source for host defense. Glucose uptake in phagocytes is mainly regulated via glucose transporter type1 (GLUT1). To examine molecular mechanisms of facilitated glucose uptake in response to fMLP or PAF, we established CHO cells stably expressing fMLP or PAF receptor with c-myc epitope tagged GLUT1 which could immunologically detect GLUT1 on the cell surface. In the CHO cells, both fMLP and PAF directly triggered GLUT1 translocation from the intracellular pool to the cell surface, and stimulated glucose uptake. Therefore, in phagocytes, we propose that fMLP and PAF also trigger GLUT1 translocation to stimulate glucose uptake as an energy source for host defense.
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| Journal Title |
The journal of medical investigation : JMI
|
| ISSN | 13431420
|
| NCID | AA11166929
|
| Volume | 47
|
| Issue | 1-2
|
| Start Page | 19
|
| End Page | 28
|
| Sort Key | 19
|
| Published Date | 2000
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| Remark | |
| EDB ID | |
| FullText File | |
| language |
eng
|
| departments |
Institute of Advanced Medical Sciences
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