N-cadherin expression in SpCC
Nguyen, Phuong Thao Hiroshima University
Kudo, Yasusei Hiroshima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Yoshida, Maki Hiroshima University
Iizuka, Shinji Hiroshima University
Ogawa, Ikuko Hiroshima University
Takata, Takashi Hiroshima University
spindle cell squamous cell carcinoma
Spindle cell carcinoma (SpCC) is a biphasic tumor composed of conventional squamous cell carcinoma and a malignant spindle cell component. SpCC expresses both epithelial and mesenchymal markers by immunohistochemical analysis. There is mounting evidence for sarcomatoid transformation from the epithelial component, supporting the theory that SpCC is a monoclonal neoplasm originating from a stem cell giving rise to both components. The loss of E-cadherin and the gain of N-cadherin expression are known as the “cadherin switching”. Cadherin switching is a major hallmark of epithelial-mesenchymal transition (EMT). EMT is a crucial process in cancer progression providing cancer cells with the ability to escape from the primary focus, to invade stromal tissues and to migrate to distant regions. Although E-cadherin down-regulation is well known in various cancers, there are a few studies on N-cadherin expression in cancer. Here, therefore, we investigated N-cadherin expression in the progression of head and neck SpCC. First we examined cadherin swithching in our established SpCC cell lines, SpCC-1 and SpCC-2. SpCC-1 and SpCC-2 cells were spindle in shape and showed cadherin switching. Moreover, we examined N-cadherin expression in 15 SpCC cases by immunohistochemistry. Although N-cadherin expression was not observed in non-neoplastic squamous epithelium, high expression of N-cadherin was observed in 10 of 15 SpCC cases. Interestingly, 6 of 7 SpCC cases with metastasis showed high expression of N-cadherin. In conclusion, our findings suggest that N-cadherin may play an important role in metastasis of SpCC in addition to the pathogenesis of SpCC of the head and neck.
Journal of Oral Pathology & Medicine
John Wiley & Sons A/S
This is the peer reviewed version of the following article: Nguyen, P. T., Kudo, Y. , Yoshida, M. , Iizuka, S. , Ogawa, I. and Takata, T. (2011), N‐cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region. Journal of Oral Pathology & Medicine, 40: 77-82, which has been published in final form at https://doi.org/10.1111/j.1600-0714.2010.00966.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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