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ID 113587
Title Alternative
N-cadherin expression in SpCC
Author
Nguyen, Phuong Thao Hiroshima University
Yoshida, Maki Hiroshima University
Iizuka, Shinji Hiroshima University
Ogawa, Ikuko Hiroshima University
Takata, Takashi Hiroshima University
Keywords
epithelial–mesenchymal transition
N-cadherin
spindle cell squamous cell carcinoma
Content Type
Journal Article
Description
Spindle cell carcinoma (SpCC) is a biphasic tumor composed of conventional squamous cell carcinoma and a malignant spindle cell component. SpCC expresses both epithelial and mesenchymal markers by immunohistochemical analysis. There is mounting evidence for sarcomatoid transformation from the epithelial component, supporting the theory that SpCC is a monoclonal neoplasm originating from a stem cell giving rise to both components. The loss of E-cadherin and the gain of N-cadherin expression are known as the “cadherin switching”. Cadherin switching is a major hallmark of epithelial-mesenchymal transition (EMT). EMT is a crucial process in cancer progression providing cancer cells with the ability to escape from the primary focus, to invade stromal tissues and to migrate to distant regions. Although E-cadherin down-regulation is well known in various cancers, there are a few studies on N-cadherin expression in cancer. Here, therefore, we investigated N-cadherin expression in the progression of head and neck SpCC. First we examined cadherin swithching in our established SpCC cell lines, SpCC-1 and SpCC-2. SpCC-1 and SpCC-2 cells were spindle in shape and showed cadherin switching. Moreover, we examined N-cadherin expression in 15 SpCC cases by immunohistochemistry. Although N-cadherin expression was not observed in non-neoplastic squamous epithelium, high expression of N-cadherin was observed in 10 of 15 SpCC cases. Interestingly, 6 of 7 SpCC cases with metastasis showed high expression of N-cadherin. In conclusion, our findings suggest that N-cadherin may play an important role in metastasis of SpCC in addition to the pathogenesis of SpCC of the head and neck.
Journal Title
Journal of Oral Pathology & Medicine
ISSN
09042512
16000714
NCID
AA10715555
Publisher
John Wiley & Sons A/S
Volume
40
Issue
1
Start Page
77
End Page
82
Published Date
2010-11-10
Rights
This is the peer reviewed version of the following article: Nguyen, P. T., Kudo, Y. , Yoshida, M. , Iizuka, S. , Ogawa, I. and Takata, T. (2011), N‐cadherin expression is correlated with metastasis of spindle cell carcinoma of head and neck region. Journal of Oral Pathology & Medicine, 40: 77-82, which has been published in final form at https://doi.org/10.1111/j.1600-0714.2010.00966.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
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DOI (Published Version)
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language
eng
TextVersion
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departments
Oral Sciences