| ID | 109945 |
| Title Transcription | カンセツ リウマチ ニ タイスル メトトレキセート チリョウチュウ ニ コウド ノ ハンケッキュウ ゲンショウ オ キタシ シボウ シタ 5レイ ノ ケントウ
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| Title Alternative | The clinical features of 5 cases that died of severe pancytopenia under treatment with low-dose MTX for rheumatoid arthritis
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| Author |
Uemura, Munenori
The Center of Medical Education, Tokushima Prefectural Central Hospital
Morita, Yutaka
The Center of Medical Education, Tokushima Prefectural Central Hospital
Udaka, Kengo
Department of Hematology, Tokushima Prefectural Central Hospital
Sekimoto, Etsuko
Department of Hematology, Tokushima Prefectural Central Hospital
Shibata, Hironobu
Department of Hematology, Tokushima Prefectural Central Hospital
Shigekiyo, Toshio
Department of Hematology, Tokushima Prefectural Central Hospital
Ozaki, Shuji
Department of Hematology, Tokushima Prefectural Central Hospital
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| Keywords | pancytopenia
low-dose MTX
the elderly
renal insufficiency
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| Content Type |
Journal Article
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| Description | Background : Methotrexate （MTX） is placed as an anchor drug of treatment for rheumatoid arthritis （RA）. However, many cases suffered from side effects of MTX such as interstitial pneumonia and hematological toxicity. We investigated ５ cases that died of severe pancytopenia under treatment with low-dose MTX for RA.
Methods : We reviewed the clinical features of ５ cases that developed severe pancytopenia and were transferred to Tokushima Prefectural Central Hospital under treatment with low-dose MTX for RA from ２０１１-２０１５. Results : All the cases were women, and were under treatment with low-dose MTX. The periods of medication of MTX were not clear. All the cases had renal insufficiency, and had a severe infection induced by pancytopenia and some cases developed disseminated intravascular coagulation （DIC）. At once we started intensive care, but all patients died in a short term. Conclusions : Women, the elderly, and renal insufficiency can be risk factors of severe pancytopenia induced by MTX even if low dosage. We should carefully treat these patients with MTX. |
| Journal Title |
四国医学雑誌
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| ISSN | 00373699
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| NCID | AN00102041
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| Publisher | 徳島医学会
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| Volume | 71
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| Issue | 5-6
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| Start Page | 155
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| End Page | 158
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| Sort Key | 155
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| Published Date | 2015-12-25
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| FullText File | |
| language |
jpn
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| TextVersion |
Publisher
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