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ID 111703
Title Alternative
ECTOPIC HORMONE PRODUCTION AND GENE EXPRESSION IN TUMORS
Author
Saito, Shiro The University of Tokushima
Saito, Haruhiko The University of Tokushima
Content Type
Journal Article
Description
異所性ホルモン産生とはもともと非内分泌腺腫瘍によるホルモン産生を指していたが, 現在では正所性産生と考えられる場合も少なくないことが知られている。本腫瘍はペプチドホルモン,神経ペプチド,成長因子などを産生・分泌し,生化学的,免疫化学的ならびに形態学的研究により, 産生ホルモンの種類・分子多様性,複数ホルモン同時産生などに個々の腫瘍による特徴が見出される。最近,遺伝子組換え技術の進歩により多数のホルモンの遺伝子構造が解明され,ホルモン前駆体のアミノ酸配列も明らかにされた。今後,正常細胞と腫瘍細胞におけるホルモン遺伝子の相違の有無, 遺伝子発現機構およびホルモン前駆体のプロセシングの機構についての研究の発展が期待される。
Description Alternative
Recent progress in research into ectopic hormone production and hormone gene expression in tumors is reviewed. Biochemical, immunochemical and morphological studies have shown that differentiation between “ectopic " and “eulopic” has become difficult and that the types of peptide hormones, neural peptides and growth factors produced, their molecular heterogeneities and ability of plural hormone production are greatly different in each tumor. Recently, the gene structures of many hormones and amino acid sequences of hormone precursors have been determined by genetic recombination techniques. However, the nature of hormone genes, the mechanism of gene expression and the processing mechanisms of hormone precursors in normal and tumor cells remain to be studied.
Journal Title
Japanese Journal of Cancer and Chemotherapy
ISSN
03850684
21872449
NCID
AN00048354
Publisher
癌と化学療法社
Volume
12
Issue
1
Start Page
1
End Page
12
Published Date
1985-01
EDB ID
FullText File
language
jpn
TextVersion
Publisher
departments
Oral Sciences