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ID 113765
Title Alternative
A case of isolated ACTH deficiency that required 6 months for the diagnosis from onset
Author
Matsuda, Hiroya Tokushima University
Endo, Furi Tokushima University
Masuda, Shiho Tokushima University
Mitsui, Yukari Tokushima University
Akehi, Yuko Tokushima University
Keywords
isolated ACTH deficiency
adrenal insufficiency
anorexia
nausea
arthralgia
Content Type
Journal Article
Description
A 53-year-old man noticed anorexia, nausea, and arthralgia of the upper limbs in April, 201X. Since these symptoms persisted, he visited general hospital and clinic and was examined for blood chemistry, ECG, echocardiography and so on. However, he did not get a definitive diagnosis and was followed up with drip infusion of saline. The symptoms did not subside and fatigue and syncope with hypotension developed. Furthermore, he also suffered weight loss of 10 kg in few months and was referred to our hospital for more detailed examinations in October, 201X. Upon the initial examination, all his symptoms matched those of adrenal insufficiency and notable decreases of both plasma ACTH and serum cortisol level were observed. Prompt glucocorticoid supplementation improved his symptoms and the abnormal laboratory data immediately. He was diagnosed adrenal insufficiency due to isolated ACTH deficiency from the results of CRH loading test and insulin tolerance test.
Since most of the symptoms and laboratory findings are non-specific, diagnosis of adrenal insufficiency is often delayed. However, adrenal insufficiency could worsen when the patient is under stress (e.g. infection) and often be life-threatening. Glucocorticoid replacement therapy should be initiated as soon as the diagnosis is confirmed. Furthermore, educating patients and his families plays a very important role in the management of chronic adrenal insufficiency, in particular to the prevention of adrenal crisis.
Journal Title
Shikoku Acta Medica
ISSN
00373699
NCID
AN00102041
Publisher
徳島医学会
Volume
75
Issue
1-2
Start Page
69
End Page
74
Sort Key
69
Published Date
2019-04-25
FullText File
language
jpn
TextVersion
Publisher
departments
University Hospital
Medical Sciences
Institute of Advanced Medical Sciences