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ID 113596
Title Alternative
Periostin overexpression and oral cancer
Author
Siriwardena, BSMS Hiroshima University|University of Peradeniya
Ogawa, I Hiroshima University
Kitagawa, M Hiroshima University
Kitajima, S Hiroshima University
Hatano, H Hiroshima University
Tilakaratne, WM University of Peradeniya
Miyauchi, Mutsumi Hiroshima University
Takata, Takashi Hiroshima University
Keywords
periostin
oral cancer
invasion
metastasis
angiogenesis
Content Type
Journal Article
Description
Oral squamous-cell carcinoma (OSCC) is one of the most common types of human cancer. Typically OSCC cells show persistent invasion that frequently leads to local recurrence and distant lymphatic metastasis. We previously identified Periostin as the gene demonstrating the highest fold change expression in the invasive clone by comparing the transcriptional profile of parent OSCC cell line and a highly invasive clone. Here, we demonstrated that Periostin overexpression enhanced invasiveness in oral cancer cell lines. To know the role of Periostin in invasion, angiogenesis and metastasis in OSCC cases, we first examined the expression of Periostin mRNA in 31 OSCC cases by RT–PCR and Periostin protein in 74 OSCC cases by immunohistochemistry. Then, we compared the Periostin expression with invasion pattern, metastasis and blood vessel density. Periostin mRNA and protein overexpression were frequently found in OSCC cases and Periostin expression was well correlated with the invasion pattern and metastasis. Moreover, blood vessel density of Periostin-positive cases was higher than those of Periostin-negative cases. Interestingly, recombinant Periostin enhanced capillary formation in vitro in a concentration-dependant manner. In summary, these findings suggest that Periostin may promote invasion and angiogenesis in OSCC, and that Periostin can be a strong marker for prediction of metastasis in oral cancer patients.
Journal Title
British Journal of Cancer
ISSN
00070920
15321827
NCID
AA00574355
Publisher
Springer Nature
Volume
95
Issue
10
Start Page
1396
End Page
1403
Published Date
2006-10-24
Rights
This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License(http://creativecommons.org/licenses/by-nc-sa/3.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Oral Sciences