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ID 115181
Author
Miyazaki, Aiko Tokushima University
Kakiuchi, Naoya Tokushima University
Okamoto, Kazumasa Tokushima University
Keywords
Flow titration
flow ratiometry
high-throughput titration
nonaqueous titration
Japanese Pharmacopoeia drug
Content Type
Journal Article
Description
Throughput rate of flow ratiometric titration has further been enhanced by shortening the lag time from the confluence of solutions upstream to the sensing of signal downstream and by optimizing analytical parameters. Feedback-based upward and downward scans of titrand/titrant flow ratio were repeated in order to offset the effect of the lag time and thus to locate the equivalence point. Subsequent faster fixed triangular wave-controlled scans in narrower range further increased the throughput rate. Analytical parameters such as scan rate and scan range were optimized. Maximally, 46.9 titrations/min was realized with reasonable precision (RSD = 1.79%). Applicability of the method to the quantitation of the Japanese Pharmacopoeia drugs (furosemide, isoniazid and prochlorperazine maleate) was verified, where the latter two drugs were determined by nonaqueous titrations.
Journal Title
Journal of Flow Injection Analysis
ISSN
0911775X
24337374
NCID
AA10962565
Publisher
Japanese Association for Flow Injection Analysis
Volume
36
Issue
2
Start Page
97
End Page
100
Published Date
2019
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Pharmaceutical Sciences