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ID 117020
Title Alternative
乳癌周術期化学療法中に薬剤性間質性肺炎を発症した症例の検討
DIP during perioperative chemotherapy
Author
Ikeuchi, Mayumi Tokushima Municipal Hospital
Hino, Naoki Tokushima Municipal Hospital
Nishisyo, Aya Tokushima Municipal Hospital
Kanematsu, Miyuki Tokushima University
Inui, Tomohiro Tokushima University
Keywords
breast cancer
Drug-induced interstitial pneumonia
perioperative chemotherapy
Content Type
Thesis or Dissertation
Description
Purpose : Drug-induced interstitial pneumonia (DIP) that occurs during chemotherapy for breast cancer is a rare but a serious adverse event. Treatments of DIP requires interruption of breast cancer treatment, which may affect the patient’s prognosis. However, there are few reports which discuss DIP during breast cancer treatments. Purpose of this report is to make clear how DIP occurred and influenced breast cancer treatment in our hospital. Patients and Methods : A total of 74 patients who started perioperative chemotherapy in Tokushima Municipal Hospital for breast cancer from January 2019 to December 2020 were evaluated for DIP. Patients’ and tumors’ characteristics, and regimens which caused DIP were investigated. The clinical courses of the DIP patients were also followed up. Results : Twelve of the 74 patients developed DIP. All 12 patients had histories of cyclophosphamide administration ; however, the causative drug could not be determined. Ten of the 12 patients were treated with steroids, and all the patients recovered ultimately from the interstitial pneumonia. While chemotherapy was administered in six patients after mild DIP, no relapse of pneumonia was observed. Conclusion : DIP during perioperative chemotherapy for breast cancer was resolved with appropriate treatment. Patients were able to resume breast cancer treatment with minimal interruption.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
69
Issue
1-2
Start Page
107
End Page
111
Sort Key
107
Published Date
2022-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Mayumi Ikeuchiの学位論文として提出され,学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3658号
Diploma Number
甲医第1540号
Granted Date
2022-09-22
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital