number of access : ?
number of downloads : ?
ID 114392
Author
Ooguro, Yukari Tokushima University
Morimoto, Kana Tokushima University
Keywords
hypothalamic-pituitary-adrenal axis
adrenal insufficiency
chlormadinone acetate
prostate cancer
Content Type
Journal Article
Description
A 78-year-old Japanese man showed suppression of the hypothalamic-pituitary-adrenal axis during maximum androgen blockade (MAB) therapy including chlormadinone acetate (CMA) for prostate cancer. After stopping the MAB therapy, both the basal ACTH level and the response to CRH recovered. While no reports have indicated that CMA suppresses the hypothalamic-pituitary-adrenal axis in patients with prostate cancer, CMA has been shown to inhibit this axis in animals. These observations suggest that we must monitor the hypothalamic-pituitary-adrenal axis in patients treated with CMA, especially under stressful conditions.
Journal Title
Internal Medicine
ISSN
13497235
Publisher
The Japanese Society of Internal Medicine
Volume
55
Issue
24
Start Page
3623
End Page
3626
Published Date
2016-12-15
Rights
The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
University Hospital
Medical Sciences
Institute of Advanced Medical Sciences