number of access : ?
number of downloads : ?
ID 112881
Title Alternative
生殖補助医療を行っている患者において卵胞液中のキスペプチン濃度は卵成熟および性腺ホルモン値と関連している
Author
Taniguchi, Yuka The University of Tokushima
Kuwahara, Akira The University of Tokushima KAKEN Search Researchers
Tachibana, Ayaka The University of Tokushima
Yano, Yuya The University of Tokushima
Yano, Kiyohito The University of Tokushima
Yamasaki, Mikio The University of Tokushima KAKEN Search Researchers
Hinokio, Kenji The University of Tokushima
Matsuzaki, Toshiya The University of Tokushima KAKEN Search Researchers
Keywords
Assisted reproductive technology
estradiol
follicular fluid
kisspeptin
mature oocyte
Content Type
Thesis or Dissertation
Description
Purpose: To assess the kisspeptin concentrations in follicular fluid and their relationship with clinical outcomes during assisted reproductive technology.
Methods: Thirty-nine patients who were aged 24-40 years and underwent oocyte retrieval for in vitro fertilization/intracytoplasmic sperm injection participated in this study. In 65 follicular fluid samples that had been obtained from 30 patients and their blood samples, the kisspeptin levels were measured in order to investigate the correlations with their gonadal hormone levels. Venous blood samples were collected from 14 patients to investigate their plasma kisspeptin levels across different phases of assisted reproductive technology.
Results: The follicular fluid kisspeptin level was significantly higher than that of the plasma level and was positively associated with the follicular fluid estradiol concentration and with the serum estradiol and number of mature oocytes. In the plasma, the maximum concentration of kisspeptin was observed on the day of ovum pick-up and on the day of embryo transfer during ovarian stimulation for assisted reproductive technology.
Conclusion: Kisspeptin was present in the follicular fluid and the plasma kisspeptin concentration was affected by ovarian stimulation. Kisspeptin appears to affect oocyte maturation and ovulation.
Journal Title
Reproductive Medicine and Biology
ISSN
14470578
NCID
AA11706516
Publisher
Wiley|Japan Society for Reproductive Medicine
Volume
16
Issue
4
Start Page
380
End Page
385
Published Date
2018-09-16
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Yuka Taniguchiの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
Copyright © 2017 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.
This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3219号
Diploma Number
甲医第1387号
Granted Date
2018-09-27
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
University Hospital
Medical Sciences