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ID 112397
Title Alternative
ヒドロコルチゾン投与は日本人心肺停止患者の生存率改善に関連する
Author
Niimura, Takahiro Tokushima University|Okayama University
Zamami, Yoshito Tokushima University|Okayama University KAKEN Search Researchers
Koyama, Toshihiro Okayama University
Miyake, Masashi Okayama University
Koga, Tadashi Shin Nippon Biomedical Laboratories, Ltd
Harada, Keisaku Kitakyushu City Yahata Hospital
Ohshima, Ayako Okayama University
Imai, Toru Nihon University
Kondo, Yutaka Harvard Medical School
Imanishi, Masaki Tokushima University
Takechi, Kenshi Tokushima University
Horinouchi, Yuya Tokushima University
Hinotsu, Shiro Okayama University
Kano, Mitsunobu R. Okayama University
Keywords
Hydrocortisone
Cardiac arrest
Database
Content Type
Thesis or Dissertation
Description
There are few reports on hydrocortisone administration after cardiac arrest, and those that have been published included few subjects. This study aimed to evaluate the effect of hydrocortisone administration on the outcomes of patients who experienced cardiac arrest. We investigated the survival discharge rates and the length of hospital stay from cardiac arrest to discharge, stratified by use of hydrocortisone, using a Japanese health-insurance claims dataset that covers approximately 2% of the Japanese population. The study included the data of 2233 subjects who experienced either in-hospital or out-of-hospital cardiac arrest between January 2005 and May 2014. These patients were divided into two groups, based on the administration of hydrocortisone. We adjusted the baseline characteristics, medical treatment, and drug administration data of the two groups using propensity scores obtained via the inverse probability of treatment weighted method. The hydrocortisone group had a significantly higher survival discharge rate (13/61 [21.1%] vs. 240/2172 [11.0%], adjusted odds ratio: 4.2, 95% CI: 1.60–10.98, p = 0.004). In addition, the administration of hydrocortisone was independent predictor of survival to discharge (hazard ratio: 4.6, p < 0.001). The results demonstrate a correlation between hydrocortisone administration and the high rates of survival to discharge.
Journal Title
Scientific Reports
ISSN
20452322
Publisher
Springer Nature
Volume
7
Start Page
17919
Published Date
2017-12-20
Remark
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Takahiro Niimuraの学位論文として提出され, 学位審査・授与の対象となっている。

Supplementary table : srep_7_17919_s1.doc
Rights
© The Author(s) 2017
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EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3502号
Diploma Number
甲医第1488号
Granted Date
2021-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
University Hospital
Pharmaceutical Sciences