| ID | 113581 |
| Title Alternative | MMP-13 Promotes Tumor Angiogenesis
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| Author |
Kudo, Yasusei
Hiroshima University|The University of Tokushima
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Iizuka, Shinji
Hiroshima University
Yoshida, Maki
Hiroshima University
Tsunematsu, Takaaki
Hiroshima University
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Kondo, Tomoyuki
The University of Tokushima
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Subarnbhesaj, Ajiravudh
Hiroshima University
Deraz, Elsayed M.
Hiroshima University
Siriwardena, Samadarani B. S. M.
Hiroshima University
Tahara, Hidetoshi
Hiroshima University
Ishimaru, Naozumi
The University of Tokushima
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Ogawa, Ikuko
Hiroshima University
Takata, Takashi
Hiroshima University
|
| Content Type |
Journal Article
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| Description | Background: Angiogenesis is an important step in the metastatic cascade of tumors.
Results: MMP-13 itself as well as VEGF-A secretion from fibroblasts promotes angiogenesis. Indeed, MMP-13 is well correlated with blood vessel density in human cancer tissues. Conclusion: MMP-13 can be a marker for prediction of malignant behaviors and a therapeutic target in cancer. Significance: This work provides new insights regarding the role of MMP-13 in tumor angiogenesis. |
| Journal Title |
Journal of Biological Chemistry
|
| ISSN | 1083351X
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| NCID | AA1202441X
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| Publisher | The American Society for Biochemistry and Molecular Biology
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| Volume | 287
|
| Issue | 46
|
| Start Page | 38716
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| End Page | 38728
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| Published Date | 2012-09-19
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| Remark | This research was originally published in the Journal of Biological Chemistry. Yasusei Kudo, Shinji Iizuka, Maki Yoshida, Takaaki Tsunematsu, Tomoyuki Kondo, Ajiravudh Subarnbhesaj, Elsayed M. Deraz, Samadarani B. S. M. Siriwardena, Hidetoshi Tahara, Naozumi Ishimaru, Ikuko Ogawa, and Takashi Takata. Matrix Metalloproteinase-13 (MMP-13) Directly and Indirectly Promotes Tumor Angiogenesis. J. Biol. Chem. 2012; Vol:287(46) pp.38716-38728.
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| Rights | © 2012 by The American Society for Biochemistry and Molecular Biology, Inc.
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| EDB ID | |
| DOI (Published Version) | |
| URL ( Publisher's Version ) | |
| FullText File | |
| language |
eng
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| TextVersion |
Publisher
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| departments |
Oral Sciences
Medical Sciences
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