Gonchigsuren, Oyundari Tokushima University
Harada, Masafumi Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Hisaoka, Sonoka Tokushima University
Higashi, Kohei Tokushima University
Matsumoto, Yuki Tokushima University Tokushima University Educator and Researcher Directory
Sumida, Nami Tokushima University
Mori, Tatsuo Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Ito, Hiromichi Tokushima University|Naruto University of Education KAKEN Search Researchers
Mori, Kenji Tokushima University Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Miyoshi, Mitsuharu GE Healthcare
Cerebral blood flow
Magnetic resonance imaging
Thesis or Dissertation
To obtain an understanding of the correlation between hemodynamic differences and morphological changes as well as potential sex differences in children with ADHD using multi-delay pseudo-continuous arterial spin labeling (pCASL) imaging and voxel-based morphometry (VBM), especially given that previous findings are limited for girls.
Materials and methods:
We recruited 23 children with ADHD (mean age, 8.3 years; 19 boys; 4 girls) and 24 children without ADHD (mean age, 9.1 years; 13 boys; 11 girls) as controls. All participants underwent 3D multi-delay pCASL and T1-weighted imaging. The voxel-based statistical parameter mapping (SPM) method was used for group-wise comparisons.
Compared with controls, children with ADHD exhibited decreased regional cerebral blood flow (rCBF) and gray matter volume (GMV) in the left middle frontal gyrus and left postcentral gyrus. Analysis by sex revealed reduced rCBF and GMV in the left lingual gyrus and left inferior occipital gyrus in boys with ADHD versus controls and increased rCBF and GMV in the left superior frontal gyrus in girls with ADHD.
Although our results are preliminary because of small sample sizes, several brain regions exhibit changes in both cerebral perfusion and GMV in the same direction in patients with ADHD, with boys with ADHD showing decreased activity and girls with ADHD displaying increased activity in the fronto-parietal cortices.
Japanese Journal of Radiology
Japan Radiological Society|Springer Nature
|DOI (Published Version)|
|URL ( Publisher's Version )|
k3595_abstract_review.pdf 253 KB
k3595_fulltext.pdf 533 KB
|MEXT report number||
Doctor of Medical Science