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ID 115513
Author
Hayashi, Fumio Tokushima University
Takasago, Tomoya Tokushima University
Keywords
Platelet-rich plasma
Distraction osteogenesis
Skeletal muscle
Fibrosis
Content Type
Journal Article
Description
Background: Skeletal muscle fibrosis caused by an increase in collagen deposition often occurs after distraction osteogenesis. Although studies are available reporting the effects of platelet-rich plasma (PRP) on tissue healing following injury, current findings remain controversial. This study focused on determining whether PRP reduces skeletal muscle fibrosis caused by distraction osteogenesis.
Methods: Tibial osteotomies were performed on 8-week-old wild type mice, and tibiae were distracted at a rate of 0.42 mm/day for 2 weeks, starting 1 week after osteotomy. Immediately after distraction was completed (3 weeks after osteotomy), PRP or phosphate buffered saline (as a sham) was injected into the gastrocnemius (GC) muscle. The GC muscles were harvested and analyzed.
Results: The amount and area of collagenous tissue increased in both the PRP and control groups following distraction osteogenesis, but the changes were not significantly different between both groups at all time points (p = 0.89, 0.45, 0.33 and 0.52 at 4, 6, 8 and 10 weeks).
Conclusion: From this study, our results suggest that PRP did not significantly reduce skeletal muscle fibrosis due to distraction osteogenesis.
Journal Title
Journal of Experimental Orthopaedics
ISSN
21971153
Publisher
BioMed Central|Springer Nature
Volume
5
Start Page
26
Published Date
2018-07-13
Rights
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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DOI (Published Version)
URL ( Publisher's Version )
FullText File
jeo_5_26.pdf 3.26 MB
language
eng
TextVersion
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departments
University Hospital
Medical Sciences