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ID 115627
Title Alternative
前立腺特異抗原スクリーニングにより発見された前立腺癌を有する日本人血液透析患者の長期的な転帰
PSA screening in hemodialysis patients
Author
Yokota, Narushi Kawashima Hospital
Nishitani, Masaaki Kawashima Hospital
Minakuchi, Jun Kawashima Hospital
Keywords
hemodialysis
prostate cancer
PSA
Content Type
Thesis or Dissertation
Description
We investigated the long-term outcomes of the Japanese hemodialysis patients with prostate cancer detected by prostate-specific antigen (PSA) screening. Clinical data of 646 male hemodialysis patients aged 55 years or older who started yearly PSA testing in the period from January 1, 2004 to December 31, 2012 and were followed until December 31, 2017 were analyzed retrospectively. The median follow-up period was 10.4 years. Nineteen (2.9%) patients were diagnosed with prostate cancer, of whom one patient died of the disease. Androgen-deprivation therapy (ADT) was selected for primary prostate cancer treatment in 17 (89.5%) of these 19 patients. Of six prostate cancer patients who underwent primary ADT (PADT) and died of other causes, three died of infectious disease, each one died of cardiovascular disease, liver cancer, and chronic renal failure. No significant difference was observed in regard to overall survival between the prostate cancer patients with PADT and non-prostate cancer patients. Prognosis of hemodialysis patients who were diagnosed with prostate cancer during yearly PSA screening examination and mainly treated with ADT was favorable without increasing cardiovascular events. This result indicates that PSA screening may be useful for detection and management of prostate cancer even in hemodialysis patients.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
68
Issue
1-2
Start Page
42
End Page
47
Sort Key
42
Published Date
2021-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Narushi Yokotaの学位論文として提出され,学位審査・授与の対象となっている。
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3470号
Diploma Number
甲医第1475号
Granted Date
2021-01-28
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences