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ID 115982
Title Alternative
Cancer activity and bleeding events post-PCI
Author
Nishikawa, Tatsuya Osaka International Cancer Institute
Morishima, Toshitaka Osaka International Cancer Institute
Fujii, Yuki Osaka International Cancer Institute
Okawa, Sumiyo Osaka International Cancer Institute
Otsuka, Tomoyuki Osaka International Cancer Institute
Kamada, Risa Osaka International Cancer Institute
Yasui, Taku Osaka International Cancer Institute
Shioyama, Wataru Osaka International Cancer Institute
Oka, Toru Osaka International Cancer Institute
Tabuchi, Takahiro Osaka International Cancer Institute
Fujita, Masashi Osaka International Cancer Institute
Keywords
Antiplatelet therapy
Bleeding
Cancer
Percutaneous coronary intervention
Content Type
Journal Article
Description
Purpose : Limited data exist about clinically relevant bleeding events related to antiplatelet therapy after percutaneous coronary intervention (PCI) in cancer patients. We investigated the risk factors for clinically relevant bleeding events in patients with cancer after PCI with stent implantation. Patients and Methods : Patients with solid cancer subjected to first PCI were divided into active (n = 45) and non-active cancer groups (n = 44). The active group included non-operable patients on treatment or with metastasis ; the non-active included those already subjected to or for whom radical surgery was planned within 3 months after the index PCI. Results : During a median follow-up of 2.2 years, 11 bleeding events occurred, with only one occurring in the non-active cancer group. Half of them occurred during the dual-antiplatelet therapy (DAPT) period, and the rest occurred during single-antiplatelet therapy (SAPT) period. Kaplan-Meier analysis showed significantly more bleeding events in the active cancer group (p = 0.010). Multivariate Cox regression hazard analysis revealed cancer activity as a significant independent risk factor for bleeding (p = 0.023) ; but not for three-point major adverse cardiovascular events. Conclusion : Clinically relevant bleeding risk after PCI was significantly lower in non-active cancer. Active cancer group had clinically relevant bleeding during both DAPT and SAPT periods.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
68
Issue
1-2
Start Page
29
End Page
37
Sort Key
29
Published Date
2021-02
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences