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ID 116479
Title Alternative
Varying clinical presentations of NTM disease
Author
Shinohara, Tsutomu Tokushima University|Japan Agricultural Cooperatives Kochi Hospital|National Hospital Organization Kochi Hospital Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Morizumi, Shun Tokushima University|Japan Agricultural Cooperatives Kochi Hospital Tokushima University Educator and Researcher Directory
Sumitomo, Kenya Japan Agricultural Cooperatives Kochi Hospital
Keywords
nontuberculous mycobacteria
tuberculosis
acid-fast bacteria tests
extrapulmonary diseases
immune reconstitution inflammatory syndrome
Content Type
Journal Article
Description
The incidence rate of pulmonary nontuberculous mycobacterial disease (PNTMD) in Japan is the highest among major industrialized nations. Although the typical clinical course and radiological manifestations of PNTMD are different from those of pulmonary tuberculosis (TB), confusion about these mycobacterial diseases leads to a diagnostic pitfall. Diagnostic challenges include the coexistence of Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM), false positives for NTM in MTB nucleic acid amplification tests, microbial substitution, and abnormal radiological manifestations caused by NTM. Features of extrapulmonary NTM diseases, such as pleurisy, vertebral osteomyelitis, and disseminated disease, are different from the corresponding tuberculous diseases. Moreover, the immunological background of the patient (status of human immunodeficiency virus infection with or without antiviral therapy, continuation or discontinuation of immunosuppressive therapy, use of immune checkpoint inhibitor, pregnancy and delivery, etc.) influences the pathophysiology of mycobacterial diseases. This review describes the varying clinical presentations of NTM disease with emphasis on the differences from TB.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
68
Issue
3-4
Start Page
220
End Page
227
Sort Key
220
Published Date
2021-08
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
Publisher
departments
Medical Sciences