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ID 110096
Title Alternative
知覚神経節内の神経伝達物質による痛み情報伝達
Author
Omoto, Katsuhiro Tokushima University
Maruhama, Kotaro Okayama University
Terayama, Ryuji Okayama University
Yamamoto, Yumiko Okayama University
Matsushita, Osamu Okayama University
Sugimoto, Tomosada Okayama University
Oguma, Keiji Okayama University
Keywords
Botulinum toxin
mechanical allodynia
dorsal root ganglion
transmitter release
Content Type
Thesis or Dissertation
Description
Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.
Journal Title
Toxins
ISSN
20726651
Publisher
MDPI
Volume
7
Issue
8
Start Page
2906
End Page
2917
Published Date
2015-08-04
Remark
内容要旨・審査要旨・論文本文:
内容要旨:LID201704251022.pdf
審査要旨:LID201704251023.pdf
論文本文:LID201704251024.pdf
本論文は, 著者Katsuhiro Omotoの学位論文として提出され, 学位審査・授与の対象となっている。
Rights
Copyright: © 2015 Omoto et al ; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3075号
Diploma Number
甲口第418号
Granted Date
2017-03-23
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences