ID 113371
Title Alternative
多層カーボンナノチューブの吸入曝露による線維化誘導型肺胞マクロファージへの長期変化
Effect of CNT exposure on alveolar macrophages
Author
Otsuka, Kunihiro Tokushima University
Yamada, Koichi Tokushima University
Taquahashi, Yuhji National Institute of Health Sciences
Kanno, Jun Japan Organization of Occupational Health and Safety
Keywords
Carbon nanotube
Taquann methods
alveolar macrophage
fibrosis
lung
Content Type
Thesis or Dissertation
Description
Background
Nanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear.
Methods and finding
In this study, exposure to Taquann-treated multi-walled CNTs (T-CNTs) was performed using aerosols generated in an inhalation chamber. At 12 months after T-CNT exposure, alveolar inflammation with macrophage accumulation and hypertrophy of the alveolar walls were observed. In addition, fibrotic lesions were enhanced by T-CNT exposure. The macrophages in the bronchoalveolar lavage fluid of T-CNT-exposed mice were not largely shifted to any particular population, and were a mixed phenotype with M1 and M2 polarization. Moreover, the alveolar macrophages of T-CNT-exposed mice produced matrix metalloprotinase-12.
Conclusions
These results suggest that T-CNT exposure promoted chronic inflammation and fibrotic lesion formation in profibrotic macrophages for prolonged periods.
Journal Title
PLOS ONE
ISSN
19326203
Publisher
PLOS
Volume
13
Issue
10
Start Page
e0205702
Published Date
2018-10-29
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Kunihiro Otsukaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
© 2018 Otsuka et al.
This is an open access article distributed under the terms of the Creative Commons Attribution License( https://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3281号
Diploma Number
甲口第446号
Granted Date
2019-03-22
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences
Medical Sciences