ID 113373
Title Alternative
過剰な機械的負荷に曝された下顎頭軟骨に対する低出力パルス超音波照射の保護効果
LIPUS effect on osteoarthritic TMJs
Author
Fujita, Mutsumi Tokushima University
Sato-Shigeta, Minami Tokushima University
Hassan, Ali H. King Abdulaziz University
Keywords
Temporomandibular joint
Osteoarthritis
Mandibular condyle
Low-intensity pulsed ultrasound
Rats
Content Type
Thesis or Dissertation
Description
The aim of this study was to assess the effect of low-intensity pulsed ultrasound (LIPUS) application on rat temporomandibular joints (TMJs) with early-stage of osteoarthritis-like conditions induced by mechanical overloading. Fifteen-week-old male Wistar rats were divided into two experimental groups and a control group (n = 10 each). Both TMJs of all rats in one experimental group were subjected to mechanical overloading for 5 d, and those in the other experimental group were exposed to LIPUS for 20 min/d after overloading. Condyles were assessed using micro-computed tomography, histology and histomorphometry. LIPUS treatment attenuated cartilage degeneration, decreased the number of osteoclastic cells and restored the expression of aggrecan after an initial decrease induced by mechanical overloading. These results indicate that LIPUS may have a protective effect on the early progression of TMJ osteoarthritis.
Journal Title
Ultrasound in Medicine and Biology
ISSN
03015629
NCID
AA00876354
AA11541187
Publisher
Elsevier B.V.|World Federation for Ultrasound in Medicine and Biology
Volume
45
Issue
4
Start Page
944
End Page
953
Published Date
2019-02-04
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Mutsumi Fujitaの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3283号
Diploma Number
甲口第448号
Granted Date
2019-03-22
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences