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ID 114969
Title Alternative
部分的上皮間葉転換関連遺伝子による頭頚部扁平上皮癌の予後予測
Prognostic value of partial-EMT-related genes in head and neck squamous cell carcinoma by a bioinformatic analysis
Prognostic value of p-EMT-related genes in HNSCC
Author
Kisoda, Satoru Tokushima University
Shao, Wenhua Tokushima University
Jin, Shengjian Tokushima University
Keywords
Head and neck squamous cell carcinoma
Partial-epithelial-to-mesenchymal transition
prognosis
Content Type
Thesis or Dissertation
Description
Objective: Recent studies have revealed that the ability of cancer cells to undergo intermediate state of EMT, partial EMT (p-EMT) poses a higher metastatic risk rather than complete EMT. Here we examined the prognostic value of p-EMT-related genes in head and neck squamous cell carcinoma (HNSCC) by bioinformatics approaches.
Materials and Methods: We used RNA-seq data of 519 primary HNSCC cases obtained from TCGA database. We compared the expression of p-EMT-related genes in HNSCC tissues with normal tissues. We evaluated the prognostic value of p-EMT-related genes in HNSCC cases by Log-rank test. We examined the expression of p-EMT-, EMT-, and epithelial differentiation-related genes by qPCR.
Results: Among p-EMT-related genes that were highly expressed in HNSCC cases, high expression of SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 was significantly correlated with poor survival of HNSCC patients. By gene expression pattern, HNSCC cell lines were classified into three groups; epithelial phenotype, EMT-phenotype, and p-EMT phenotype.
Conclusions: Our findings suggest that p-EMT program may be involved in poor prognosis of HNSCC. SERPINE1, ITGA5, TGFBI, P4HA2, CDH13, and LAMC2 can be used for a prognostic marker. Moreover, HNSCC cells with p-EMT phenotype can be a useful model for investigating a nature of p-EMT.
Journal Title
Oral Diseases
ISSN
16010825
NCID
AA11631042
Publisher
John Wiley & Sons
Volume
26
Issue
6
Start Page
1149
End Page
1156
Published Date
2020-04-11
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Satoru Kisodaの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This is the peer reviewed version of the following article: Kisoda, S, Shao, W, Fujiwara, N, et al. Prognostic value of partial EMT‐related genes in head and neck squamous cell carcinoma by a bioinformatic analysis. Oral Dis. 2020; 26: 1149– 1156., which has been published in final form at https://doi.org/10.1111/odi.13351. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3611号
Diploma Number
甲口第479号
Granted Date
2022-03-23
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
Oral Sciences
Medical Sciences