Total for the last 12 months
number of access : ?
number of downloads : ?
ID 117148
Title Alternative
食餌性ポリリン酸は、モノリン酸よりも腎障害およびFGF23分泌に大きな影響を与える
In vivo response of dietary polyphosphate
Author
Sasaki, Sumire Tokushima University
Koike, Megumi Tokushima University
Tanifuji, Kazuya Tokushima University
Uga, Minori Tokushima University
Kawahara, Kota Tokushima University
Komiya, Aoi Tokushima University
Miura, Mizuki Tokushima University
Harada, Yamato Tokushima University
Hamaguchi, Yuki Tokushima University
Sasaki, Shohei Tokushima University
Keywords
Polyphosphate
FGF23
Kidney
Intestine
Diet
Content Type
Thesis or Dissertation
Description
Phosphate (Pi)-containing food additives are used in several forms. Polyphosphate (PPi) salt has more harmful effects than monophosphate (MPi) salt on bone physiology and renal function. This study aimed to analyze the levels of parathyroid hormone PTH and fibroblast growth factor 23 (FGF23) and the expression of renal / intestinal Pi transport-related molecules in mice fed with an MPi or PPi diet. There were no significant differences in plasma Pi concentration and fecal Pi excretion levels between mice fed with the high-MPi and PPi diet. However, more severe tubular dilatation, interstitial fibrosis, and calcification were observed in the kidneys of mice fed with the high PPi diet versus the MPi diet. Furthermore, there was a significant increase in serum FGF23 levels and a decrease in renal phosphate transporter protein expression in mice fed with the PPi diet versus the MPi diet. Furthermore, the high MPi diet was associated with significantly suppressed expression and activity of intestinal alkaline phosphatase protein. In summary, PPi has a more severe effect on renal damage than MPi, as well as induces more FGF23 secretion. Excess FGF23 may be more involved in inflammation, fibrosis, and calcification in the kidney.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
69
Issue
3-4
Start Page
173
End Page
179
Sort Key
173
Published Date
2022-08
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Sumire Sasakiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3637号
Diploma Number
甲栄第292号
Granted Date
2022-03-30
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences