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ID 118208
Title Alternative
糖尿病患者におけるうま味味覚感度は食品摂取と口腔内環境に関連する
Umami taste sensitivity in diabetes
Author
Kawakami, Ayuka Tokushima University
Takashi, Tomoe Tokushima University
Sugiuchi, Mizuki Tokushima University
Hyodo, Mizusa Tokushima University
Mishima, Yuna Tokushima University
Keywords
Umami
taste sensitivity
Diabetes
Food intake
Oral environments
Content Type
Thesis or Dissertation
Description
Objective : Dysgeusia is a serious problem in patients with diabetes because it often leads to overeating, which is associated with disease progression. This study aimed to investigate the association between taste sensitivity, eating habits, and the oral environment. Subjects and methods : In this cross-sectional study of 75 subjects with diabetes, gustatory function was assessed using the whole-mouth method, and lingual taste receptor gene expression was measured by real-time PCR. Food intake was evaluated using a food frequency questionnaire based on food groups. The oral environment was assessed using xerostomia and periodontal comprehensive examination. Results : In total, 45.3%, 28.0%, and 18.7% of subjects showed lower umami taste sensitivity, low sweet taste sensitivity, and low salt taste sensitivity, respectively. Lower umami sensitivity correlated with lower estimated glomerular filtration rate and higher energy-source food intake. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression than those with lower plaque control record. Conclusion : Reduced umami taste sensitivity is associated with decreased renal function and high energy food intake in diabetes. Subjects with diabetes with higher plaque control record showed significantly higher T1R3 gene expression, suggesting that the oral environment affects taste gene expression.
Journal Title
The Journal of Medical Investigation
ISSN
13496867
13431420
NCID
AA11166929
Publisher
Tokushima University Faculty of Medicine
Volume
70
Issue
1-2
Start Page
241
End Page
250
Sort Key
241
Published Date
2023-02
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Ayuka Kawakamiの学位論文として提出され,学位審査・授与の対象となっている。
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3708号
Diploma Number
甲栄第296号
Granted Date
2023-03-23
Degree Name
Doctor of Nutritional Science
Grantor
Tokushima University
departments
Medical Sciences
Institute of Advanced Medical Sciences
University Hospital