Mitamura, Yoshinori Tokushima University|Japan Clinical Retina Study Group Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Enkhmaa, Tserennadmid Tokushima University|Japan Clinical Retina Study Group
Sano, Hiroki Tokushima University|Japan Clinical Retina Study Group
Niki, Masanori Tokushima University|Japan Clinical Retina Study Group Tokushima University Educator and Researcher Directory
Murao, Fumiko Tokushima University|Japan Clinical Retina Study Group Tokushima University Educator and Researcher Directory
Egawa, Mariko Tokushima University|Japan Clinical Retina Study Group Tokushima University Educator and Researcher Directory KAKEN Search Researchers
Sonoda, Shozo Japan Clinical Retina Study Group|Kagoshima University
Sakamoto, Taiji Japan Clinical Retina Study Group|Kagoshima University
Thesis or Dissertation
To examine the choroidal change accompanying retinal vein occlusion (RVO) in detail, we measured changes in choroidal structure after intravitreal aflibercept (IVA) injections for RVO using binarisation of enhanced depth imaging optical coherence tomographic (EDI-OCT) images and assessed associations with clinical outcome.
Retrospective, observational case series. Forty treatment-naïve patients (10 central, 18 major branch and 12 macular branch RVO) were examined by EDI-OCT before and 1, 3 and 6 months after IVA injections. EDI-OCT images were binarised using ImageJ. Subfoveal cross-sectional areas of the luminal, stromal and total choroid over a 1500 µm span were measured and the stromal area to total choroidal area (S/C) ratio was calculated.
Compared to normal contralateral eyes, afflicted eyes at baseline exhibited significantly greater stromal area (p<0.001), total choroidal area (p=0.001) and S/C ratio (p<0.001), but no difference in luminal area (p=0.083). The stromal area, S/C ratio and total choroidal area were significantly reduced in afflicted eyes at 1, 3 and 6 months after IVA (all p<0.006). Baseline S/C ratio was significantly correlated with baseline visual acuity (VA), baseline central retinal thickness (CRT) and VA and CRT improvement at 1, 3 and 6 months post-treatment even after adjusting for the axial length, age and sex (all p<0.012).
RVO induces substantial oedema of the choroidal stromal area that is detectable by binarisation of EDI-OCT images. This stromal oedema likely stems from high intraocular vascular endothelial growth factor levels. Changes in choroidal structure may be used to assess severity and prognosis of RVO.
British Journal of Ophthalmology
BMJ Publishing Group
This is an open access article distributed in accordance with the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is noncommercial. See: http://creativecommons.org/licenses/by-nc/4.0/
|DOI (Published Version)|
|URL ( Publisher's Version )|
k3668_abstract.pdf 121 KB
k3668_review.pdf 103 KB
k3668_fulltext.pdf 921 KB
|MEXT report number||
Doctor of Medical Science