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ID 118291
Title Alternative
ファルネソイドX受容体に対する刺激はマクロファージのM2分極化を促進する
Author
Jaroonwitchawan, Thiranut Tokushima University
Keywords
ファルネソイドX受容体
ファルネソイドX受容体アゴニスト
M2マクロファージ
レチノール酸受容体
farnesoid X receptor
macrophage
cell differentiation
inflammation
tissue repair
Content Type
Thesis or Dissertation
Description
FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in macrophage polarization. In this paper we demonstrated that stimulation of macrophages derived from the bone marrow using an FXR agonist activated polarization toward M2 but not M1 macrophages. The treatment of mice with chitin skewed macrophage polarization towards M2 macrophages, while co-treatment with an FXR agonist further promoted the polarization toward M2 macrophages in vivo. This skewed polarization towards M2 macrophages by an FXR agonist was accompanied by increased expression of signaling molecules related to the retinoic acid receptor. Inhibition of the retinoic acid receptor suppressed FXR agonist-mediated M2 macrophage polarization, indicating that this polarization was, at least, partly dependent on the retinoic acid receptor pathway. These data demonstrate that FXR has a role in polarization toward M2 macrophages and suggest a possible therapeutic potential of FXR agonists in M2 macrophage-related conditions.
Journal Title
Frontiers in Immunology
ISSN
16643224
Publisher
Frontiers Media S.A.
Volume
14
Start Page
1065790
Published Date
2023-01-27
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Thiranut Jaroonwitchawanの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3701号
Diploma Number
甲医第1571号
Granted Date
2023-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences
Institute of Post-LED Photonics