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ID 116994
Title Alternative
造影剤濃度と緩和能の定量的パラメータマッピングと脳腫瘍細胞外pH
Author
Taniguchi, Yo FUJIFILM Healthcare Corporation
Ono, Masaharu FUJIFILM Healthcare Corporation
Bito, Yoshitaka FUJIFILM Healthcare Corporation
Keywords
MRI
QPM
pHe
pH
細胞外pH
Content Type
Thesis or Dissertation
Description
In clinical magnetic resonance imaging, gadolinium-based contrast agents are commonly used for detecting brain tumors and evaluating the extent of malignancy. We present a new method to evaluate relaxivity (r1) and contrast agent concentration separately in contrast-enhanced lesions using quantitative parameter mapping (QPM). Furthermore, we also aimed to estimate the extracellular pH (pHe) of tumor lesions. We demonstrated that it is possible to evaluate pathophysiological tumor changes due to therapeutic efficacy by measuring r1 in contrast-enhanced lesions. In this study, the primary brain tumor group showed significantly higher r1 values than other brain disease groups (P < 0.001). Moreover, mean pHe value showed a trend for tumor malignancy having a lower pHe value and primary brain tumor having a significantly lower pHe than other brain diseases (P < 0.001). Our results might suggest that QPM can separately quantify r1 and CA concentration in brain tumors and that pHe brain tumor mapping could serve as a tumor biomarker. In conclusion, our method has potential clinical applications for assessing the treatment effects.
Journal Title
Scientific Reports
ISSN
20452322
Publisher
Springer Nature
Volume
12
Start Page
2171
Published Date
2022-02-09
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Yuki Matsumotoの学位論文として提出され,学位審査・授与の対象となっている。
Rights
Tis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3599号
Diploma Number
甲医第1532号
Granted Date
2022-03-23
Degree Name
Doctor of Medical Science
Grantor
Tokushima University
departments
Medical Sciences