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ID 117036
Title Alternative
金属アレルギーはTSLP-TSLPRシグナルを介して口腔扁平苔癬の発症に関与する
Author
Yunizar, Mohammad Fadyl Tokushima University
Liu, Lipei Tokushima University
Keywords
metal allergy
oral lichen planus
TSLP-TSLPR
Content Type
Thesis or Dissertation
Description
Metal allergy is a T-cell-mediated delayed type of hypersensitive reaction. The pathogenetic mechanisms underlying the allergy are unclear, although the condition has been reported to be related to oral lichen planus (OLP), despite an absence of immunological studies to support this relationship. In this study, histopathological samples of OLP patients were examined to compare the metal allergy-positive and -negative groups, with a focus on the network of epidermal keratinocytes and T cells induced by thymic stromal lymphopoietin (TSLP) and its receptor, TSLPR. Infiltration of T cells into the epithelium was revealed to be higher in the OLP lesions of metal allergy-positive patients than in those of metal allergy-negative patients. Moreover, TSLP-TSLPR signaling and TNF-α production were higher in the epithelial tissue samples of the metal allergy-positive patients than in the metal allergy-negative patients. Metal allergy is associated with both increased expressions of TSLP in keratinocytes and increased TNF-α levels in the epithelium. We propose that this would promote the accumulation of T cells at the lesion site, contributing to the formation of the disease. These results suggest that metal allergy may be an aggravating factor in the pathogenesis of OLP.
Journal Title
Journal of Clinical Medicine
ISSN
20770383
Publisher
MDPI
Volume
11
Issue
3
Start Page
519
Published Date
2022-01-20
Remark
内容要旨・審査要旨・論文本文の公開
本論文は,著者Mohammad Fadyl Yunizarの学位論文として提出され,学位審査・授与の対象となっている。
Rights
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
EDB ID
DOI (Published Version)
URL ( Publisher's Version )
FullText File
language
eng
TextVersion
ETD
MEXT report number
甲第3613号
Diploma Number
甲口第483号
Granted Date
2022-03-23
Degree Name
Doctor of Dental Science
Grantor
Tokushima University
departments
University Hospital
Oral Sciences