ID 111969
著者
Omoto, Katsuhiro Tokushima University
Maruhama, Kotaro Okayama University
Terayama, Ryuji Okayama University
Yamamoto, Yumiko Okayama University
Matsushita, Osamu Okayama University
Sugimoto, Tomosada Okayama University
Oguma, Keiji
キーワード
botulinum toxin
mechanical allodynia
dorsal root ganglion
transmitter release
資料タイプ
学術雑誌論文
抄録
Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.
掲載誌名
Toxins
ISSN
20726651
出版者
MDPI
7
8
開始ページ
2906
終了ページ
2917
発行日
2015-08-04
権利情報
© 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article
distributed under the terms and conditions of the Creative Commons Attribution license(http://creativecommons.org/licenses/by/4.0/).
EDB ID
297100
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系