Atherosclerotic cardiovascular disease
Low-density lipoprotein cholesterol
American College of Cardiology and American Heart Association
Statin-associated muscle symptoms
Statins can decrease lowering level of Low-Density Lipoprotein Cholesterol (LDL-C), and have been effective for prevention of Atherosclerotic Cardiovascular Disease (ASCVD). Lipid-Lowering Therapy (LLT) has been prevalent, but some cases develop statin intolerance. Cases with statin intolerance may show Statin-Associated Muscle Symptoms (SAMS). SAMS includes various clinical manifestations, such as general malaise, mild weakness, muscle pain and cramps with about 5-10% of incidence in clinical practice. European Atherosclerosis Society (EAS) consensus panel included three SAMS types, which are myalgias, myositis and rhabdomyolysis. There is a proposal of algorithm for the management of SAMS with several stages such as genesis, exams, diagnosis, evaluation and management. As non-statin based therapies, ezetimibe and Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) inhibitors can be added and applied.
Research and Case Reports on Clinical and Experimental Cardiology
Scholars Insight Publishers
This work is licensed under a Creative Commons Attribution 4.0 International License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted se, distribution, and reproduction in any medium, provided the original work is properly cited.
rcrcec_1_1_101.pdf 324 KB