Inclisrian statin dyslipidemia
Atherosclerotic cardiovascular disease (ASCVD)
Up-to-date pharmacological topics for inclisiran and statin for dyslipidemia are described. The efficacy of inclisiran has been reported for reduction of LDL-C values. Inclisiran has been involved in gene silencing, which brings selective inhibition of a protein by targeting its mRNA. For RCTs of inclisiran, ORION 10/11 studies were conducted, where inclisiran and control groups were followed 1.5 years. LDL-C reduced in 53.8%/49.2%. RCTs of 19 meta-analyses showed whether statins will prolong life and its degree. As a result, statin can delay onset of events compared to placebo for cardiovascular death 9.3 days, myocardial infarction 18 days, and stroke 6.1 days.
SunText Review of Endocrine Care
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