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ID 115432
著者
Fujikawa, T Kanaiso Hospital
Kato, Y Kanaiso Hospital
板東, 浩 Kanaiso Hospital|Tokushima University KAKEN研究者をさがす
Kakutani, H Kanaiso Hospital
Kawata, T Kanaiso Hospital
Yamamoto, M Kanaiso Hospital
Wada, K Kanaiso Hospital
Ishikura, K Kanaiso Hospital
Shirai, Y Kanaiso Hospital
Narutaki, M Kanaiso Hospital
Matsuzaki, S Kanaiso Hospital
Waka, S Kanaiso Hospital
キーワード
Xultophy
Insulin Degludec/Liraglutide (IDegLira)
Type 2 Diabetes Mellitus
Hemodialysis
資料タイプ
学術雑誌論文
抄録
Background: Recent diabetic treatments include Insulin Degludec/ liraglutide (IDeg/Lira, Xultophy) in clinical practice. Authors have continued clinical research concerning diabetes, chronic renal failure, dialysis, and others.
Subjects and Methods: Ten patients with type 2 diabetes mellitus (T2DM) undergoing hemodialysis were investigated. They showed that ages 74.5 ± 5.9 years, M/F=6/4, BMI 21.1± 3.8kg/m2, hemodialysis duration 8.1 ± 5.7 years. At the beginning, fundamental data were Cre 8.2 ± 1.9 mg/dL, HbA1c 6.5 ± 0.8%. Xultophy was started on 5-12 doses and continued for 6 months with the same or 1-4 increased doses for better glycemic variability.
Results: Out of 10 subjects, the changes in HbA1c showed a decrease in 7, stable in 2, and an increase in 1. HbA1c value was 6.2 ± 0.8% in average at 6 months. There were no remarkable adverse effects by Xultophy for 6 months.
Discussion and Conclusion: Xultophy was started at 5-12 doses, which were remarkably lower doses than usual doses with satisfactory efficacy. One of the reasons may be from the characteristic of the patients, who were diabetic with undergoing hemodialysis. Another factor is possibly from liraglutide, which has hepatic clearance with potential vascular protective effects. These results are expected to become reference data for future research.
掲載誌名
Diabetes Research : Open Access
出版者
Asploro
2
3
開始ページ
72
終了ページ
78
発行日
2020-10-20
権利情報
© 2020 Fujikawa T, Kato Y, Bando H, Kakutani H, Kawata T, Yamamoto M, Wada K, Ishikura K, Shirai Y, Narutaki M, Matsuzaki S, Waka S. This is an open-access article distributed under the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系