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ID 116111
著者
板東, 浩 Tokushima University|Integrative Medicine Japan KAKEN研究者をさがす
キーワード
Dyslipidemia
Inclisiran
Statin
Atherosclerotic Cardiovascular Disease (ASCVD)
LDL-C
資料タイプ
学術雑誌論文
抄録
Current topics for dyslipidemia are described. Elderly people receiving statin (n=326,981) for 6.8 years showed reduced hazard ratio (HR) as total mortality 0.75, and cardiovascular mortality 0.80. Taking n-3 unsaturated fatty acids >3g daily reduced relative ratio (RR) as sudden death 0.70, stroke 0.74 and cardiac death 0.82. As LDL-C is reduced every 1.0 mmol/L (38.67 mg/dL), cardiovascular event will be reduced by 21%. The efficacy of inclisiran has been reported for reducing LDL-C value. In large RCTs of ORION 10/11 studies, patients with atherosclerotic cardiovascular disease (ASCVD) receiving inclisiran for 510 days showed decreased LDL-C ratio as 53.8%/49.2%.
掲載誌名
International Journal of Endocrinology and Diabetes
ISSN
26943875
出版者
Pubtexto Publishers
3
2
開始ページ
117
発行日
2021-06-17
権利情報
This is an open-access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系