アクセス数 : ?
ダウンロード数 : ?
ID 110962
タイトル別表記
大腸癌肝転移におけるThrombospondin-1発現の役割とその分子メカニズム
著者
寺奥, 大貴 徳島大学大学院医科学教育部(医学専攻)
Yoshikawa, Masato University of Tokushima
東島, 潤 University of Tokushima KAKEN研究者をさがす
キーワード
大腸癌
肝転移
THBS-1
HIF-1
EMT
Thrombospondin-1
colorectal liver metastasis
immunohistochemistry
資料タイプ
学位論文
抄録
Background/Purpose
Thrombospondin-1 (THBS-1), a glycoprotein, is an endogenous inhibitor of angiogenesis and tumor growth. In this study, we investigated the clinical role and mechanism of THBS-1 expression in colorectal liver metastases, focusing on the relationships between its expression and tumor growth, epithelial–mesenchymal transition (EMT), and expression of other relevant molecules.
Methods
Ninety-four patients who initially underwent curative hepatic resection were enrolled in this study and correlations between expression of THBS-1 (THBS-1 high [n=35] and THBS-1 low [n=59]) and tumor growth, Ki-67 labelling index (Ki-67 LI), expression of other relevant molecules, and microvessel density (MVD) investigated.
Results
THBS1 low expression correlated with more advanced grade of liver and lymph node metastases and significantly worse overall survival than strong THBS1 expression (3-year survival: 96.7% vs. 65.4%, p<0.01). Multivariate analysis identified THBS1 low expression as an independent prognostic factor (HR=2.82, 95% CI=1.21–7.71, p=0.01). THBS-1 low expression correlated positively with high Ki-67 LI (p<0.05) and inversely with E-cadherin (p<0.05) and hypoxia inducible factor-1α (HIF-1α) expression (p<0.05); THBS-1 expression and MVD were not significantly correlated.
Conclusions
Low THBS-1 expression may be an independent poor prognostic factor that affects tumor growth and EMT acquisition. Additionally, THBS-1 may be regulated by the HIF-1 pathway.
掲載誌名
Journal of Hepato-Biliary-Pancreatic Sciences
ISSN
18686974
18686982
cat書誌ID
AA12507209
出版者
Japanese Society of Hepato‐Biliary‐Pancreatic Surgery|Wily
23
9
開始ページ
565
終了ページ
573
発行日
2016-07-12
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Hiroki Teraokuの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3118号
学位記番号
甲医第1353号
学位授与年月日
2017-10-26
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院