ID 112321
タイトル別表記
Gender and coronary artery bypass graft surgery
著者
Maimaituxun, Gulinu Tokushima University
島袋, 充生 Tokushima University|Fukushima Medical University KAKEN研究者をさがす
Salim, Hotimah Masdan Tokushima University
Tabata, Minoru Sakakibara Heart Institute
Yuji, Daisuke Shonan-Kamakura General Hospital
Morimoto, Yoshihisa Awaji Medical Center
Akasaka, Takeshi Shonan-Kamakura General Hospital
Sugimoto, Takaki Awaji Medical Center
Tanaka, Masashi Shonan-Kamakura General Hospital
Takanashi, Shuichiro Sakakibara Heart Institute
資料タイプ
学術雑誌論文
抄録
Background
Traditional and non-traditional risk factors for atherosclerotic cardiovascular disease (ASCVD) are different between men and women. Gender-linked impact of epicardial adipose tissue volume (EATV) in patients undergoing coronary artery bypass grafting (CABG) remains unknown.

Methods
Gender-linked impact of EATV, abdominal fat distribution and other traditional ASCVD risk factors were compared in 172 patients (men: 115; women: 57) who underwent CABG or non-coronary valvular surgery (non-CABG).

Results
In men, EATV, EATV index (EATV/body surface area) and the markers of adiposity such as body mass index, waist circumference and visceral fat area were higher in the CABG group than in the non-CABG group. Traditional ASCVD risk factors were also prevalent in the CABG group. In women, EATV and EATV index were higher in the CABG group, but other adiposity markers were comparable between CABG and non-CABG groups. Multivariate logistic regression analysis showed that in men, CABG was determined by EATV Index and other ASCVD risk factors including hypertension, dyslipidemia, adiponectin, high sensitive C-reactive protein (hsCRP) and type 2 diabetes mellitus (Corrected R2 = 0.262, p < 0.0001), while in women, type 2 diabetes mellitus is a single strong predictor for CABG, excluding EATV Index (Corrected R2 = 0.266, p = 0.005).

Conclusions
Our study found that multiple risk factors, including epicardial adipose tissue volume and traditional ASCVD factors are determinants for CABG in men, but type 2 diabetes mellitus was the sole determinant in women. Gender-specific disparities in risk factors of CABG prompt us to evaluate new diagnostic and treatment strategies and to seek underlying mechanisms.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
12
6
開始ページ
e0177170
発行日
2017-06-08
権利情報
Copyright: © 2017 Maimaituxun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系
病院