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ID 109704
タイトル別表記
成長期における咀嚼性刺激の減少が下顎骨の性状に及ぼす影響
Effects of Decreased Loading on the Mandible
著者
七條, なつ子 徳島大学大学院口腔科学教育部(口腔科学専攻) KAKEN研究者をさがす
Ruijven, Leo J. van University of Amsterdam and VU University Amsterdam
Langenbach, Geerling E. J. University of Amsterdam and VU University Amsterdam
キーワード
muscle activity
loading stimulus
bone remodeling
mineralization
資料タイプ
学位論文
抄録
Background
Bone mass and mineralization are largely influenced by loading. The purpose of this study was to evaluate the reaction of the entire mandibular bone in response to decreased load during growth. It is hypothesized that decreased muscular loading will lead to bone changes as seen during disuse, i.e. loss of bone mass.
Methods and Findings
Ten 21-day-old Wistar strain male rats were divided into two groups (each n=5) and fed on either a hard- or soft-diet for 11 weeks. Micro-computed tomography was used for the investigation of bone mineralization, bone volume, bone volume fraction (BV/TV) and morphological analysis. Mandibular mineralization patterns were very consistent, showing a lower degree of mineralization in the ramus than in the corpus. In the soft-diet group, mineralization below the molars was significantly increased (p<0.05) compared to the hard diet group. Also, bone volume and BV/TV of the condyle and the masseter attachment were decreased in the soft-diet group (p<0.05). Morphological analysis showed inhibited growth of the ramus in the soft-diet group (p<0.05).
Conclusion
Decreased loading by a soft diet causes significant changes in the mandible. However, these changes are very region-specific, probably depending on the alterations in the local loading regime. The results suggest that muscle activity during growth is very important for bone quality and morphology.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
10
6
開始ページ
e0129290
発行日
2015-06-10
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨 : LID201606141001.pdf
審査要旨 : LID201606141002.pdf
論文本文 : LID201606141003.pdf
本論文は, 著者Natsuko Hichijoの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
Copyright: © 2015 Hichijo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第2939号
学位記番号
甲口第404号
学位授与年月日
2016-03-23
学位名
博士(歯学)
学位授与機関
徳島大学
部局
病院
歯学系