アクセス数 : ?
ダウンロード数 : ?
ID 111279
著者
Miyatake, Yumiko Tokushima University
志内, 哲也 Tokushima University|Japan Science and Technology Agency 徳島大学 教育研究者総覧 KAKEN研究者をさがす
Ueta, Tomoyo Tokushima University
Taniguchi, Yasuko Tokushima University
Futami, Akari Tokushima University
Sato, Fukiko Tokushima University
Kitamura, Tadahiro Gunma University
キーワード
Adiponectin
spontaneous activity
brain
資料タイプ
学術雑誌論文
抄録
Enhancing exercise motivation is the best way to prevent obesity and diabetes. In this study, we examined whether adiponectin affects locomotion activity in Wister and Spontaneously-Running Tokushima-Shikoku (SPORTS) rats using two types of behavioral assays : home cage and wheel running activity. SPORTS rats were established from an original line from Wister strain that had shown high level of wheel running activity in our laboratory. Injection of adiponectin into the lateral ventricle of Wister rats and SPORTS rats decreased home cage activity, but no change was observed in the food intake and oxygen consumption. This result indicates the possibility that adiponectin can reduce non-exercise activity thermogenesis (NEAT) and physical activity via the central nervous system. In contrast, injection of adiponectin did not change wheel running activity in SPORTS rats. We produced hypothalamus-destructed model rat using monosodium glutamate (MSG) to elucidate the regulation site of adiponectin. Injection of adiponectin into MSG-treated SPORTS rats did not change amount of home cage activity and food intake, suggesting that adiponectin action on home cage activity was in the hypothalamic area. These results suggest that adiponectin regulates locomotion activity through mediobasal hypothalamus.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
62
3-4
開始ページ
199
終了ページ
203
並び順
199
発行日
2015-08
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系