アクセス数 : ?
ダウンロード数 : ?
ID 111416
著者
Terai, Tomoya Tokushima University
Goel, Vijay K. University of Toledo
Biyani, Ashok University of Toledo
Ebraheim, Nabil University of Toledo
林, 二三男 Tokushima University
Morimoto, Masatoshi Tokushima University
眞鍋, 裕昭 Tokushima University
キーワード
Ligamentum flavum
Epiligament
Lumbar spinal canal stenosis
Collagenous fiber
Fibrosis
資料タイプ
学術雑誌論文
抄録
Ligamentum flavum (LF) hypertrophy is one of the main factors of lumbar spinal canal stenosis (LSCS). The primary object of this study is to clarify the existence of epiligament in the LF and its role in hypertrophy, and to develop an LF hypertrophy animal model. A cadaveric spine from a 30-year-old man was used to investigate the existence of epiligament in LF. Five LF samples from LSCS patients were obtained to evaluate hypertrophied LF. To create a rat model, we destabilized the lumbar spine. Each LF was sagittally cut for histological evaluation. The epiligament was clearly evident in normal LF specimens, which stained pink on Elastica van Gieson and green on Masson Trichrome. Onelayer was observed on the dural side and another on the dorsal side of the LF. LSCS patients had an enlarged dorsal epiligament, at around 30 times that of the regular thin epiligament on the dural side. The destabilized rat model showed an enlarged dorsal epiligament, with a mean thickness 8-fold that of the control. LF hypertrophy may be due to enlargement of the dorsal epiligament. Mechanical loading of the LF is an important factor for inducing hypertrophy in the rat model.
掲載誌名
The Journal of Medical Investigation
ISSN
13496867
13431420
cat書誌ID
AA11166929
AA12022913
出版者
Faculty of Medicine Tokushima University
65
1-2
開始ページ
85
終了ページ
89
並び順
85
発行日
2018-02
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系