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ID 113577
著者
Iizuka, Shinji Sanford-Burnham Medical Research Institute
キーワード
matrix metalloproteinase
invasion
angiogenesis
head and neck squamous cell carcinoma
資料タイプ
学術雑誌論文
抄録
Extracellular matrix degradation by matrix metalloproteinases (MMPs) plays a pivotal role in cancer progression by promoting motility, invasion and angiogenesis. Studies have shown that MMP expression is increased in head and neck squamous cell carcinomas (HNSCCs), one of the most common cancers in the world, and contributes to poor outcome. In this review, we examine the expression pattern of MMPs in HNSCC by microarray datasets and summarize the current knowledge of MMPs, specifically MMP-1, -3, -7 -10, -12, -13, 14 and -19, that are highly expressed in HNSCCs and involved cancer invasion and angiogenesis.
掲載誌名
Cancers
ISSN
20726694
出版者
MDPI
6
1
開始ページ
396
終了ページ
415
発行日
2014-02-13
権利情報
© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系