ID 112969
著者
Taniguchi, Yuka The University of Tokushima
Tachibana, Ayaka The University of Tokushima
Yano, Yuya The University of Tokushima
矢野, 清人 The University of Tokushima
山﨑, 幹雄 The University of Tokushima KAKEN研究者をさがす
Hinokio, Kenji The University of Tokushima
キーワード
assisted reproductive technology
estradiol
follicular fluid
kisspeptin
mature oocyte
資料タイプ
学術雑誌論文
抄録
Purpose: To assess the kisspeptin concentrations in follicular fluid and their relationship with clinical outcomes during assisted reproductive technology.
Methods: Thirty-nine patients who were aged 24-40 years and underwent oocyte retrieval for in vitro fertilization/intracytoplasmic sperm injection participated in this study. In 65 follicular fluid samples that had been obtained from 30 patients and their blood samples, the kisspeptin levels were measured in order to investigate the correlations with their gonadal hormone levels. Venous blood samples were collected from 14 patients to investigate their plasma kisspeptin levels across different phases of assisted reproductive technology.
Results: The follicular fluid kisspeptin level was significantly higher than that of the plasma level and was positively associated with the follicular fluid estradiol concentration and with the serum estradiol and number of mature oocytes. In the plasma, the maximum concentration of kisspeptin was observed on the day of ovum pick-up and on the day of embryo transfer during ovarian stimulation for assisted reproductive technology.
Conclusion: Kisspeptin was present in the follicular fluid and the plasma kisspeptin concentration was affected by ovarian stimulation. Kisspeptin appears to affect oocyte maturation and ovulation.
掲載誌名
Reproductive Medicine and Biology
ISSN
14470578
cat書誌ID
AA11706516
出版者
Japan Society for Reproductive Medicine|John Wiley & Sons Australia, Ltd
16
4
開始ページ
380
終了ページ
385
発行日
2017-09-16
権利情報
© 2017 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系