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ID 111437
タイトル別表記
骨髄由来線維細胞は肺がん細胞のがん幹細胞様特性を増強する
著者
西條, 敦郎 徳島大学大学院医科学教育部(医学専攻) KAKEN研究者をさがす
Nakano, Mayuri Tokushima University
Mitsuhashi, Atsushi Tokushima University
キーワード
Lung cancer
Cancer stem cell
Fibrocyte
Tumor microenvironment
AKT pathway
資料タイプ
学位論文
抄録
Cancer stem cells (CSCs) represent a minor population that have clonal tumor initiation and self-renewal capacity and are responsible for tumor initiation, metastasis, and therapeutic resistance. CSCs reside in niches, which are composed of diverse types of stromal cells and extracellular matrix components. These stromal cells regulate CSC-like properties by providing secreted factors or by physical contact. Fibrocytes are differentiated from bone marrow-derived CD14þ monocytes and have features of both macrophages and fibroblasts. Accumulating evidence has suggested that stromal fibrocytes might promote cancer progression. However, the role of fibrocytes in the CSC niches has not been revealed. We herein report that human fibrocytes enhanced the CSC-like properties of lung cancer cells through secreted factors, including osteopontin, CC-chemokine ligand 18, and plasminogen activator inhibitor-1. The PIK3K/AKT pathway was critical for fibrocytes to mediate the CSC-like functions of lung cancer cells. In human lung cancer specimens, the number of tumor-infiltrated fibrocytes was correlated with high expression of CSC-associated protein in cancer cells. These results suggest that fibrocytes may be a novel cell population that regulates the CSC-like properties of lung cancer cells in the CSC niches.
掲載誌名
Cancer Letters
ISSN
03043835
cat書誌ID
AA00598513
AA1152274X
出版者
Elsevier
421
開始ページ
17
終了ページ
27
発行日
2018-02-12
備考
内容要旨・審査要旨・論文本文の公開
権利情報
© 2018 Published by Elsevier B.V.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3131号
学位記番号
甲医第1365号
学位授与年月日
2018-03-20
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院