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タイトル別表記
肺癌における腫瘍浸潤線維細胞の走化因子とその疾患予後に及ぼす影響についての解析
CHEMOTACTIC FACTORS FOR TUMOR-INFILTRATING FIBROCYTES IN LUNG CANCER
著者
飛梅, 亮 徳島大学大学院医学研究科(医学専攻) KAKEN研究者をさがす
Afroj, Tania Tokushima University
キーワード
C‑X‑C chemokine receptor type 4
C‑X‑C motif chemokine 12
LUAD
NSCLC
fibrocyte
資料タイプ
学位論文
抄録
Fibrocytes, which are bone marrow‑derived collagen‑producing cells, have been reported to be involved in pathogenesis of pulmonary fibrosis. Our previous study reported that tumor‑infiltrating fibrocytes play a role in tumor progression and drug resistance in lung cancer. The present study therefore examined chemotactic factors for fibrocytes in tissues of non‑small cell lung cancer (NSCLC) and their prognostic significance. Surgically resected tumor tissues were examined for the expression of chemotactic factors, including C‑X‑C motif chemokine 12 (CXCL12), CCL2, platelet‑derived growth factor (PDGF)‑AA and PDGF‑BB, as well as tumor‑infiltrating fibrocytes by immunostaining. The chemotactic ability of fibrocytes in response to each factor was evaluated using a migration assay by counting the migrated cells microscopically, and expression of receptors for chemotactic factors were analyzed by flow cytometry. The expression of CXCL12, but not CCL2, PDGF‑AA, or PDGF‑BB, was associated with the number of tumor‑infiltrating fibrocytes in lung adenocarcinoma (LUAD), but not lung squamous cell carcinoma (LUSQ). In addition, patients with an increased expression of CXCL12 in LUAD but not LUSQ showed a significantly poorer prognosis compared with those with a decreased expression. However, the expression of CCL2, PDGF‑AA and PDGF‑BB was not correlated with the prognosis of patients with NSCLC. The number of fibrocytes was associated with a poor prognosis in LUAD. Fibrocytes derived from the peripheral blood of healthy subjects as well as patients with lung cancer expressed higher levels of CXCR4 compared with CCR2, PDGF and receptor‑α and receptor‑β. Overall, these results suggested that targeting tumor‑infiltrating fibrocytes via the CXCL12/CXCR4 axis may be a useful strategy for controlling the progression of NSCLC, particularly LUAD.
掲載誌名
Oncology Letters
ISSN
17921074
17921082
出版者
Spandidos Publications
24
5
開始ページ
417
発行日
2022-09-30
備考
内容要旨・審査要旨・論文本文の公開
本論文は,著者Makoto Tobiumeの学位論文として提出され,学位審査・授与の対象となっている。
権利情報
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.( https://creativecommons.org/licenses/by-nc-nd/4.0/ )
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3677号
学位記番号
甲医第1561号
学位授与年月日
2023-02-24
学位名
博士(医学)
学位授与機関
徳島大学
部局
病院
医学系