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ID 79137
著者
テシガワラ, キヨシ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School|Division of Biofunctional Evaluation Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama
保坂, 利男 Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School
山口, 美輪 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
テラダ, エリ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
キシュク, ユカ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
フクナガ, ケイコ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
ヒラタ, ヨウコ Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
Jambaldorj, Bayasgalan Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School
原田, 永勝 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School KAKEN研究者をさがす
酒井, 徹 Department of Public Health and Applied Nutrition, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
中屋, 豊 Department of Nutrition and Metabolism, Institute of Health Biosciences, the University of Tokushima Graduate School 徳島大学 教育研究者総覧 KAKEN研究者をさがす
キーワード
HBA
hyperlipidemia
TNFα
MCP1
資料タイプ
学術雑誌論文
抄録
Hyperbaric air (HBA) is used to improve healing of wounds including diabetic
ulcer. The aim of this study was to clarify the effects of HBA exposure on lipid and glucose
metabolism in db/db mice. HBA did not influence the weight of db/db mice. Serum
levels of free fatty acid and triglyceride, but not glucose and insulin, were significantly
decreased after 6 weeks of treatment with HBA. The mRNA expressions of CPT-1, PPARα
and PGC-1α genes, which are related to lipid metabolism, were significantly up-regulated
in the muscle and liver. Increases in TNFα and MCP1 mRNA, which impaired lipid metabolism,
were also attenuated by HBA treatment. These results suggest that exposure
of HBA could have beneficial effects on lipid metabolism in patients with type 2 diabetes
mellitus.
掲載誌名
The journal of medical investigation : JMI
ISSN
13431420
cat書誌ID
AA11166929
57
3-4
開始ページ
224
終了ページ
231
並び順
224
発行日
2010-08
備考
The journal of medical investigation : http://medical.med.tokushima-u.ac.jp/jmi/index.html
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
部局
医学系