アクセス数 : ?
ダウンロード数 : ?
ID 114401
著者
Obata, Fumiaki Tokushima University
松浦, 元一 Tokushima Red Cross Hospital KAKEN研究者をさがす
岸, 史 Tokushima University
キーワード
Light Chain Proximal Tubulopathy (LCPT)
IgD λ myeloma
paraprotein related kidney disease
資料タイプ
学術雑誌論文
抄録
Light Chain Proximal Tubulopathy (LCPT) is a rare form of paraprotein-related kidney disease in which monoclonal free light chains damage the proximal renal tubular epithelial cells. We herein report the case of a 78-year-old woman who presented with anemia and kidney dysfunction. Serum and urine protein electrophoresis analyses revealed a monoclonal IgD and λ free light chains. Proximal tubular injury and the accumulation of λ light chains were found by kidney biopsy. Electron microscopy revealed no organized structure suggestive of crystals. LCPT was caused by IgD lambda myeloma and bortezomib and dexamethasone therapy led to very good partial response (VGPR) without a worsening of the kidney function.
掲載誌名
Internal Medicine
ISSN
13497235
出版者
The Japanese Society of Internal Medicine
57
24
開始ページ
3597
終了ページ
3602
発行日
2018-12-15
権利情報
The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
病院
医学系