ID 113527
タイトル別表記
Effect of CNT exposure on alveolar macrophages
著者
Otsuka, Kunihiro Tokushima University
Yamada, Koichi Tokushima University
Taquahashi, Yuhji National Institute of Health Sciences
Kanno, Jun Japan Organization of Occupational Health and Safety
資料タイプ
学術雑誌論文
抄録
Background
Nanomaterials are widely used in various fields. Although the toxicity of carbon nanotubes (CNTs) in pulmonary tissues has been demonstrated, the toxicological effect of CNTs on the immune system in the lung remains unclear.

Methods and finding
In this study, exposure to Taquann-treated multi-walled CNTs (T-CNTs) was performed using aerosols generated in an inhalation chamber. At 12 months after T-CNT exposure, alveolar inflammation with macrophage accumulation and hypertrophy of the alveolar walls were observed. In addition, fibrotic lesions were enhanced by T-CNT exposure. The macrophages in the bronchoalveolar lavage fluid of T-CNT-exposed mice were not largely shifted to any particular population, and were a mixed phenotype with M1 and M2 polarization. Moreover, the alveolar macrophages of T-CNT-exposed mice produced matrix metalloprotinase-12.

Conclusions
These results suggest that T-CNT exposure promoted chronic inflammation and fibrotic lesion formation in profibrotic macrophages for prolonged periods.
掲載誌名
PLOS ONE
ISSN
19326203
出版者
PLOS
13
10
開始ページ
e0205702
発行日
2018-10-29
権利情報
© 2018 Otsuka et al. This is an open access article distributed under the terms of the Creative Commons Attribution License(https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
歯学系
医学系