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ID 110034
タイトル別表記
Secreted Frizzled-Related Protein-1発現低下は肝内胆管癌において予後不良と関係している
著者
ダバドルジ, マンダハナラン 徳島大学大学院医科学教育部(医学専攻)
寺奥, 大貴 Tokushima University
吉川, 雅登 Tokushima University
キーワード
Intrahepatic cholangiocarcinoma
Prognostic factor
SFRP1
β-Catenin
資料タイプ
学位論文
抄録
Aims: Secreted Frizzled-Related Protein-1 (SFRP1) is a well-known negative regulator of the wingless type (Wnt)-β-catenin pathway and its inactivation plays an important role in the development and progression of many cancers. In this study, we aimed to determine the clinical significance of SFRP1 expression in intrahepatic cholangiocarcinoma (IHCC) and to define the relationship to Wnt-β-catenin pathway.
Methods: Fifty IHCC patients who had liver resection were enrolled in this study. SFRP1 protein expression was examined by immunohistochemistry in tumor tissues. The patients were divided into two groups: SFRP1 positive (n=30) and negative (n=20). Clinicopathological characteristics were analyzed.
Results: SFRP1 significantly correlated with curability (Cur A, B vs. C, p=0.029); and recurrent pattern (intrahepatic vs. extrahepatic, p=0.010). The negative SFRP1 group had significantly poorer prognosis, and 5-year survival rates were 8.1% of the negative SFRP1 group and 44.6% of the positive SFRP1 group, respectively. Moreover, the disease-free survival rate in the negative SFRP1 group was significantly poorer ( p < 0.001). Multivariate analysis revealed that loss of SFRP1served as an independent prognostic factor in IHCC for both overall (HR, 2.923; 95% CI, 1.30-6.56; p=0.009) and disease-free (HR, 2.631; 95% CI, 1.31-5.27; p=0.006) survival. In addition, SFRP1 expression negatively correlated to β-catenin expression ( p=0.005).
Conclusions: Those results suggested that the loss of SFRP1 could be a poor prognostic factor for IHCC, through the Wnt-β-catenin pathway.
掲載誌名
European Journal of Surgical Oncology
ISSN
07487983
cat書誌ID
AA10516435
出版者
Elsevier
43
2
開始ページ
344
終了ページ
350
発行日
2016-12-24
備考
内容要旨・審査要旨・論文本文の公開:
内容要旨・審査要旨:LID201704121001.pdf
論文本文:LID201704121002.pdf
本論文は, 著者M. Davaadorjの学位論文として提出され, 学位審査・授与の対象となっている。
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3008号
学位記番号
甲医第1312号
学位授与年月日
2017-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系
病院