Alcohol Intake and Serum Lipids–Genetic Modification
Sasakabe, Tae Nagoya University
Wakai, Kenji Nagoya University
Kawai, Sayo Nagoya University
Hishida, Asahi Nagoya University
Naito, Mariko Nagoya University
Suzuki, Sadao Nagoya City University
Nindita, Yora Kagoshima University|Diponegoro University
Kita, Yoshikuni Tsuruga Nursing University
Hara, Megumi Saga University
Kuriyama, Nagato Kyoto Prefectural University of Medicine
Hirata, Akie Kyushu University
Mikami, Haruo Chiba Cancer Center
Oze, Isao Aichi Cancer Center
Kubo, Michiaki RIKEN
Tanaka, Hideo Aichi Cancer Center|Nagoya University
Hamajima, Nobuyuki Nagoya University
Background: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated.
Methods: We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study.
Results: The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was −2.49 mg/dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (−3.24 mg/dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated.
Conclusions: The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men.
Journal of Epidemiology
Japan Epidemiological Association
© 2017 Tae Sasakabe et al. This is an open access article distributed under the terms of Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. (https://creativecommons.org/licenses/by/4.0/)
jepide_28_4_185.pdf 666 KB