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Edaravoneによる正常眼圧緑内障モデルマウスの網膜神経節細胞死の抑制
Edaravone prevents normal tension glaucoma
著者
赤岩, 慶 徳島大学大学院医科学教育部(医学専攻)
Namekata, Kazuhiko Tokyo Metropolitan Institute of Medical Science
Azuchi, Yuriko Tokyo Metropolitan Institute of Medical Science
Guo, Xiaoli Tokyo Metropolitan Institute of Medical Science
Kimura, Atsuko Tokyo Metropolitan Institute of Medical Science
Harada, Chikako Tokyo Metropolitan Institute of Medical Science
Harada, Takayuki The University of Tokushima
キーワード
edaravone
NTG
oxidative stress
EAAC1
free radical
資料タイプ
学位論文
抄録
Glaucoma, one of the leading causes of irreversible blindness, is characterized by progressive degeneration of optic nerves and retinal ganglion cells (RGCs). In the mammalian retina, excitatory amino-acid carrier 1 (EAAC1) is expressed in neural cells, including RGCs. Loss of EAAC1 leads to RGC degeneration without elevated intraocular pressure (IOP) and exhibits glaucomatous pathology including glutamate neurotoxicity and oxidative stress. In the present study, we found that edaravone, a free radical scavenger that is used for treatment of acute brain infarction and amyotrophic lateral sclerosis (ALS), reduces oxidative stress and prevents RGC death and thinning of the inner retinal layer in EAAC1-deficient (KO) mice. In addition, in vivo electrophysiological analyses demonstrated that visual impairment in EAAC1 KO mice was ameliorated with edaravone treatment, clearly establishing that edaravone beneficially affects both histological and functional aspects of the glaucomatous retina. Our findings raise intriguing possibilities for the management of glaucoma by utilizing a widely prescribed drug for the treatment of acute brain infarction and ALS, edaravone, in combination with conventional treatments to lower IOP.
掲載誌名
Cell Death & Disease
ISSN
20414889
出版者
Springer Nature
8
開始ページ
e2934
発行日
2017-07-13
備考
内容要旨・審査要旨・論文本文の公開
本論文は, 著者Kei Akaiwaの学位論文として提出され, 学位審査・授与の対象となっている。
権利情報
© The Author(s) 2017 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
EDB ID
出版社版DOI
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
博士論文全文を含む
文科省報告番号
甲第3126号
学位記番号
甲医第1360号
学位授与年月日
2018-03-23
学位名
博士(医学)
学位授与機関
徳島大学
部局
医学系