直近一年間の累計
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ID 112000
著者
Ebe, Koji Takao Hospital
Muneta, Tetsuo Muneta Maternity Clinic
板東, 正浩 Tokushima University
Yonei, Yoshikazu Doshisha University
キーワード
(IGI-carbo70) Insulinogenic index-carbohydarate 70 g
(CR) Calorie restriction
(LCD) Low carbohydrate diet
(T2DM) Type 2 diabetes mellitus
(IRI) Immunoreactive insulin
資料タイプ
学術雑誌論文
抄録
Background: The discussion has continued concerning Calorie Restriction (CR) and Low Carbohydrate Diet (LCD) for years. Authors and colleagues have continued clinical research on LCD. In this study, CR diet was given to diabetic patients and the new evaluation way of insulinogenic index-carbohydrate 70 g (IGI-carbo70) would be proposed.
Subjects and methods: The subjects were 48 patients with Type 2 diabetes mellitus (T2DM) and admitted for 14 days for further evaluation and treatment. CR diet was provided on day 1 and 2, including 60% carbohydrate, 25% lipids and 15% protein with 1400 kcal/day. On the morning of day 2, breakfast with 70 g of carbohydrate was given, and blood glucose and immune reactive insulin (IRI) at 0 and 30 min and IGI were investigated.
Results: Average HbA1c was 7.9% and Morbus (M) value was 108 in median. Glucose and IRI on 0-30 min significantly increased as 166-212 mg/dL, 4.3-1.9 μU/mL, respectively. Classified into 3 groups as to HbA1c level, low, middle and high group showed HbA1c 6.0%, 7.8%, 9.7%, respectively. Glucose and IRI on 0-30 min in median were 117-50, 166-203, 218-299 mg/dL, 4.4-12.8, 4.5-13.5, 4.2-9.9 μU/mL, with IGI 0.25, 0.14, 0.10, respectively.
Discussion and conclusion: Newly-proposed IGI-carbo70 was investigated, and there were several correlations among 8 related biomarkers. These findings suggest that current results would become the fundamental data and IGIcarbo70 could be the useful way to evaluate diabetic status by usual meal with mixed nutrients.
掲載誌名
Journal of Clinical and Experimental Endocrinology
出版者
OMICS International
1
1
開始ページ
102
発行日
2017-10-18
権利情報
Copyright: © 2017 Bando H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
出版社版URL
フルテキストファイル
言語
eng
著者版フラグ
出版社版
部局
医学系